Understanding HIV Biology for Development of New Therapeutic Strategies

The Torbett Lab studies HIV entry, evolution, and assembly at the genomic, biochemical and structural levels, as well as human hematopoietic stem cell resistance of HIV lentiviral vector entry.

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June 23rd, 2022
Congratulations to Christian Gallardo for his manuscript “Selective ablation of 3′ RNA ends and processive RTs facilitate direct cDNA sequencing of full-length host cell and viral transcripts”, published in Nucleic Acids Research. Thanks to co-authors and close collaborators at the Routh Lab at UTMB.

May 26th, 2022
Christian Gallardo gave an oral presentation at the “Transcription and Splicing” session at the 2022 Retroviruses Meeting at Cold Spring Harbor Laboratory reporting on his studies developing novel sequencing approaches to simultaneously sequence full-length host cell and HIV-1 transcripts without PCR amplification.

May 18th, 2022
Eirini Vamva gave an oral presentation at the 25th annual American Society of Gene and Cell Therapy reporting on her studies using a Lentiviral Vector to deliver the eCD4-Ig immunoadhesin to human B cells to enable HIV-1 neutralization.

May 11th, 2022
Congratulations to Kristina Seiler for her manuscript “Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions”, published in Cell Death and Disease. Thanks to co-authors and close collaborators at the Tschan Lab at University of Bern.

March 18th, 2022
Congrats to Eirini Vamva for her manuscript “An optimized measles virus glycoprotein-pseudotyped lentiviral vector production system to promote efficient transduction of human primary B cells“, now published in STAR Protocols (Cell Press). Thanks to co-authors and collaborators at the Verhoeyen, James, and Rawlings Lab.

January 8th, 2022
Congratulations to Shiyi Wang for her manuscript “Covariation of viral recombination with single nucleotide variants during virus evolution revealed by CoVaMa”, now published in Nucleic Acids Research. Thanks to co-authors and close collaborators at the Routh Lab at UTMB.

October 19th, 2021
Eirini Vamva presents a Poster at the European Society for Gene and Cell Therapy Annual Congress on her work using Lentiviral Vector Delivery of eCD4-Ig to support HIV-1 neutralization.

July 9th, 2021
Congratulations to senior author Christian Gallardo, and Shiyi Wang, for their manuscript “MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution”, now published in Nucleic Acids Research. Thanks to co-authors and collaborators at UCSD and UTMB.