View Torbett Lab publications from NCBI


142. Sotcheff S, Zhou Y, Yeung J, Sun Y, Johnson JE, Torbett BE , Routh AL, ViReMa: a virus recombination mapper of next-generation sequencing data characterizes diverse recombinant viral nucleic acids, GigaScience, Volume 12, 2023, giad009,

141. Vamva E, Ozog S, Leaman DP, Cheng RY, Irons NJ, Ott A, Stoffers C, Khan I, Goebrecht GK, Gardner MR, Farzan M, Rawlings DJ, Zwick MB, James RJ, Torbett BE. A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-Knob-in-Hole-Reversed immunoadhesin. Molecular Therapy-Methods & Clinical Development. 2023 Feb 11.


140. Shah, R., Gallardo, C.M., Jung, Y.H., Clock, B., Dixon, J.R., McFadden, W.M., Majumder, K., Pintel, D.J., Corces, V.G., Torbett, B.E. and Tedbury, P.R., 2022. Activation of HIV-1 proviruses increases downstream chromatin accessibility. iScience, 25(12), p.105490.

139. Gallardo CM, Nguyen AT, Routh AL, Torbett BE. Selective Ablation of 3′ RNA ends and Processive RTs Facilitate Direct cDNA Sequencing of Full-length Host cell and Viral Transcripts. Nucleic Acids Research. gkac516,

138. Seiler, K., Humbert, M., Minder, P., Mashimo, I., Schläfli, A.M., Krauer, D., Federzoni, E.A., Vu, B., Moresco, J.J., Yates, J.R. and Sadowski, M.C., 2022. Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Cell death & disease, 13(5), pp.1-14. PMID: 35538058

137. D’Souza, S.S., Kumar, A., Maufort, J., Weinfurter, J.T., Raymond, M., Strelchenko, N.S., Perrin, E., Coonen, J., Mejia, A., Simmons, H.A. and Torbett, B.E., 2022. Assessment of Safety and Immunogenicity of MHC homozygous iPSC-derived CD34+ Hematopoietic Progenitors in a NHP Model. Blood Advances. PMID: 35404997

136. Vamva E, Ozog S, Verhoeyen E, James RG, Rawlings DJ, Torbett BE. An optimized measles virus glycoprotein-pseudotyped lentiviral vector production system to promote efficient transduction of human primary B cells. STAR Protoc. 2022 Mar 8;3(1):101228. doi: 10.1016/j.xpro.2022.101228. PMID: 35284833; PMCID: PMC8914380.

135. Chupradit, K., Khamaikawin, W., Sakkhachornphop, S., Puaninta, C., Torbett, B.E., Borwornpinyo, S., Hongeng, S., Wattanapanitch, M. and Tayapiwatana, C., 2022. Engineered Zinc Finger Protein Targeting 2LTR Inhibits HIV Integration in Hematopoietic Stem and Progenitor Cell-Derived Macrophages: In Vitro Study. International Journal of Molecular Sciences, 23(4), p.2331. PMID: 35216446. PMCID: PMC8875109.

134. Gallardo CM, Nguyen AT, Routh AL, Torbett BE. Selective Ablation of 3′ RNA ends and Processive RTs Facilitate Direct cDNA Sequencing of Full-length Host cell and Viral Transcripts. bioRxiv 2022.01.27.478099; doi: Accepted at Nucleic Acids Research

133. Wang S, Sotcheff SL, Gallardo CM, Jaworski E, Torbett BE, Routh AL. Co-variation of viral recombination with single nucleotide variants during virus evolution revealed by CoVaMa. Nucleic Acids Research, PMID: 35018461


132. Wang S, Sotcheff SL, Gallardo CM, Jaworski E, Torbett BE, Routh AL. Co-variation of viral recombination with single nucleotide variants during virus evolution revealed by CoVaMa. . Accepted at Nucleic Acids Research

131. Gallardo CM, Wang S, Montiel-Garcia DJ, Little SJ, Smith DM, Routh AL, Torbett BE. MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution. Nucleic Acids Res. 2021 Jul 9;49(12):e70. doi: 10.1093/nar/gkab231.PMID: 33849057

130. Zhuang S, Torbett BE. Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics. Viruses. 2021 Mar 5;13(3):417. doi: 10.3390/v13030417. PMID: 33807824

129. Deng Y, Hammond JA, Pauszek R, Ozog S, Chai I, Rabuck-Gibbons J, Lamichhane R, Henderson SC, Millar DP, Torbett BE, Williamson JR. Discrimination between Functional and Non-functional Cellular Gag Complexes involved in HIV-1 Assembly. J Mol Biol. 2021 Apr 16;433(8):166842. doi: 10.1016/j.jmb.2021.166842. Epub 2021 Feb 1. PMID: 33539875


128. Guo LT, Adams RL, Wan H, Huston NC, Potapova O, Olson S, Gallardo CM, Graveley BR, Torbett BE. Sequencing and Structure Probing of Long RNAs Using MarathonRT:A Next-Generation Reverse Transcriptase. Pyle AM. J Mol Biol. 2020 May 1;432(10):3338-3352. doi: 10.1016/j.jmb.2020.03.022. Epub 2020 Apr 4. PMID: 32259542


127. Delviks-Frankenberry KA, Ackerman D, Timberlake ND, Hamscher M, Nikolaitchik OA, Hu WS, Torbett BE, Pathak VK. Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G. Mol Ther Nucleic Acids, 2019 Dec 6;18:1023-1038. doi: 10.1016/j.omtn.2019.10.024. Epub 2019 Oct 31.PMID: 31778955

126. Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D’Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Sluvkin I, Ryu BY, Sorrentino BP, Adair JE, Snyder Sa, Compton AA, Torbett BE. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood, 2019 Aug 15. doi: 10.1182/blood.2019000040. PMID 31416800


125. Ozog S, Chehen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. CD46 Null Pckaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Mol Ther Methofs Clin Dev. 2018 Nov 24;13:27-39 PMID: 30603655; PMCID: PMC6310745.

124. Shi G, Ozog S, Torbett BE, Compton AA. mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10069-E10078. doi: 10.1073/pnas.1811892115. Epub 2018 Oct 9. PMID: 30301809

123. Jin J, Britschgi A, Schläfli AM, Humbert M, Shan-Krauer D, Batliner J, Federzoni EA, Ernst M, Torbett BE, Yousefi S, Simon HU, Tschan MP. Oxid Med Cell Longev. Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. 2018 Mar 18. doi: 10.1155/2018/1482795.  PMID: 29743969

122. Iwasaki M, Minder P, Caì Y, Kuhn JH, Yates JR 3rd, Torbett BE, de la Torre JC. Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. PLoS Pathog. 2018 Feb 20. doi: 10.1371/journal.ppat.1006892. PMID: 29462184 

121. Heffner GC, Bonner M, Christiansen L, Pierciey FJ, Campbell D, Smurnyy Y, Zhang W, Hamel A, Shaw S, Lewis G, Goss KA, Garijo O, Torbett BE, Horton H, Finer MH, Gregory PD, Veres G. Mol Ther. Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells. 2018 Jan 3. doi: 10.1016/j.ymthe.2017.09.025. PMID: 29102562


120. Haimovici A, Humbert M, Federzoni EA, Shan-Krauer D, Brunner T, Frese S, Kaufmann T, Torbett BE. PU.1 supports TRAIL-induced cell death by inhibiting NF-kB-mediated cell survival and inducing DR5 expression. Cell Death Differ. 2017 Mar 31. doi: 10.1038/cdd.2017.10. PMID: 28362429

119. Flynn WF, Haldane A, Torbett BE, Levy RM. Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease. Mol Biol Evol. 2017 Mar 20. doi: 10.1093/molbev/msx095. PMID: 28369521; PMCID: PMC 5435099


118. Baird, A., Deng, C., Eliceiri, M.H., Haghi, F., Dang, X., Coimbra, R., Costantini, T.W., Torbett, B.E., Eliceiri, B.P. Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo. Wound Repair Regen. 2016 Sep 24. doi: 10.1111/wrr.12471. PMID: 27663454

117. Weber MR, Zuka M, Lorger M. Tschan M, Torbett BE, Zijstra A, Quigley JP, Staflin K, Eliceiri BP, Kruger JS, Marchese P, Ruggeri ZM, Felding BH. Activated tumor cell integrin αvβ3 ooperates with platelets to promote extravasation and metastasis from the blood stream. Thromb Res. 2016 Apr;140. Suppl 1:S27-36. doi: 10.1016/S0049-3848(16)30095-0. PMID: 27067975


116. Torbett BE, Goodsell DS, Richard DD, editors. The Future of HIV-1 Therapeutics: Resistance is Futile?. Berlin: Springer, 2015.

115. Wampfler, J., Federzoni, E.A., Torbett, B.E., Fey, M.F., Tschan, M.P. The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation. Leuk Res. 2015 Dec 19.  PMID: 26740055

114. Kang, H., Minder, P., Park, M.A., Mesquitta, W.T., Torbett, B.E., Slukvin, I.I. CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus. Mol Ther Nucleic Acids. 2015 Dec 15. PMID: 26670276

113. Routh A, Chang MW, Okulicz JF, Johnson JE, Torbett BE.CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data.Methods. 2015.  PMID:26408523

112. Khamaikawin W, Saoin S, Nangola S, Chupradit K, Sakkhachornphop S, Hadpech S, Onlamoon N, Ansari AA, Byrareddy SN, Boulanger P, Hong SS, Torbett BE, Tayapiwatana C.Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly.Mol Ther Nucleic Acids. 2015.  PMID: 26305555; PMCID: PMC4684750

111. Friedmann T, Jonlin EC, King NM, Torbett BE, Wivel NA, Kaneda Y, Sadelain M.ASGCT and JSGT Joint Position Statement on Human Genomic Editing.Mol Ther. 2015 Aug. PMID:26227250

110. Tschan MP, Federzoni EA, Haimovici A, Britschgi C, Moser BA, Jin J, Reddy VA, Sheeter DA, Fischer KM, Sun P, Torbett BE.Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.Biochim Biophys Acta. Sept 2015. PMID:26187004; PMCID: PMC4687731

109. Torbett BE, Goodsell DS, Richman DD. Preface. Curr Top Microbiol Immunol. 2015.PMID:26086053

108. Wang CX, Torbett BE.Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.Curr Opin Hematol. July 2015.PMID:26049750; PMCID: PMC4688901

107. Wampfler J, Federzoni EA, Torbett BE, Fey MF, Tschan MP.Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells. J Leukoc Biol. Sep 2015. PMID: 25990244

106. Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP.Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Leuk Res Rep. Apr 2015. PMID: 25984443

105. Flynn WF, Chang MW, Tan Z, Oliveira G, Yuan J, Okulicz JF, Torbett BE, Levy RM.Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease.PLoS Comput Biol. Apr 2015. PMID: 25894830; PMCID: PMC4404092

104. Mori, M., Kovalenko, L., Lyonnais, S., Antaki, D., Torbett, B.E., Botta, M., Mirambeau, G., Mély, Y. Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1. Curr Top Microbiol Immunol. 2015. PMID: 25749978

103.Torbett, B. E., Baird, A., Eliceiri, B. P.  Understanding the rules of the road: proteomic approaches to interrogate the blood brain barrier. Frontiers in Neuroscience. Mar 2015 9  DOI:10.3389/fnins.2015.00070  PMID:25788875; PMCID: PMC4349081

102. Costantini, T.W., Meads, M., Dang, X., Coimbra, R., Torbett, B.E., Baird, A., and Eliceiri, B. The Response to Burn Injury in Mice with Human Hemato-Lymphoid Systems.  Ann Surg. 2015 Jan 8. PMID:25575256; PMCID: PMC6550477


101. Barclay, S., Yang, Y., Zhang, S., Fong, R., Barraza, A., Torbett, B.E., Abedi, M., Bauer, G., Jan A. Nolta, and Anderson, JS. Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells. Stem Cells. 2014 Dec 19. doi: 10.1002/stem.1919. (PMID:25524029). PMC Journal in Process

100. Garg, D., Torbett, B.E. Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy. Virus Res. 2014 Jul 12. pii: S0168-1702(14)00270-6. PMID: 25026536; PMCID: PMC4252855

99. Haimovici, A., Brigger, D., Torbett, B.E., Fey, M.F., Tschan M.P. Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.Leukemia Research. 2014 Sept;38(9):1041-7. Epub2014Jul1. (PMID: 25043887). PMC Journal in Process

98. Wang, C.X., Sather, B.D., Wang, X., Adair, J., Khan, I., Singh, S., Lang, S., Adams, A., Curinga, G., Kiem, H.P., Miao, C.H., Rawlings, D.J., Torbett, B.E. Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Blood. 2014 Jun 9. pii: blood-2013-12-546218. PMCID:PMC4126331

97. Federzoni EA, Humbert M, Torbett BE, Behre G, Fey MF, Tschan MP. CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation. Sci Rep. 2014 Mar 3;4:4261. PMCID: PMC3939455

96. Amirache F, Lévy C, Costa C, Mangeot PE, Torbett BE, Wang CX, Nègre D, Cosset FL, Verhoeyen E. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood. 2014 Feb 27;123(9):1422-4. PMID: 24578496

95. Humbert M, Federzoni EA, Britschgi A, Schläfli AM, Valk PJ, Kaufmann T, Haferlach T, Behre G, Simon HU, Torbett BE, Fey MF, Tschan MP. The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. J Leukoc Biol. 2014 Jan;95(1):83-93. PMCID: PMC386818

94. Breuer S., Espinola, S., Morelli, X., Harris, J.L., Torbett, B.E., Arold, S.T., and Engels, I.H.  A biochemical/biophysical assay dyad for HTS-compatible triaging of inhibitors of the HIV-1 Nef/Hck SH3 interaction. Current Chemical Genomics and Translational Medicine. 2013 Jul 26; 7:16-20. (PMID:24396731


93. Brigger D., Torbett, B.E., Chen J, Fey M.F., Tschan M.P. Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. Biochem Biophys Res Commun. 2013 Aug 23;438(2):283-8. PMID: 23891751; PMCID: PMC4225710

92. Tiefenbrunn (Sample), T., Forli, S., Baksh, M., Chang, M.W., Happer, M., Lin, Y-C., Perryman, A.L., Rhee, J-K., Torbett, B.E., Olson, A.J., Elder, J.H., Finn, M.G., and Stout, C.D.  Small Molecule Regulation of Protein Conformation by Binding in the Flap of HIV Protease. ACS Chem Biol. 2013 Mar 29. [Epub ahead of print] PMID: 23540839; PMCID: PMC3769432

91. Chang, M.W., Oliveira, G., Yuan, J., Okulicz, J.F., Levy, S., Torbett, B.E. Rapid deep sequencing of patient-derived HIV with ion semiconductor technology. J Virol Methods. 189(1):232-4, 2013. (PMCID: PMC3608812)

90. Federzoni, E.A., Magali Humbert, M., Valk, P.J.M., Behre, G., Leibundgut, E.O., Torbett, B.E., Fey, M.F., and Tschan, M.P. The actin-binding protein CORO1A is inhibited in APL and CEBPA-mutated AML patients but its expression can be restored during neutrophil differentiation via PU.1-and CEBPA-mediated activation. Brit. J. Haematol. 160(6):855-859, 2013. (PMID: 23252456)


89. Schlafli, A.M., Torbett, B.E., Fey, M.F., and Tschan, M.P. BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation. Exp. Hematol. Oncol.1(1):25, 2012. (PMCID: PMC3514096)

88. Joshi, P., Sloan, B., Torbett, B.E., and Stoddart, C.A. Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology 436(1):162-172, 2012. (PMCID: PMC3563299)

87. Yusuf, D., et al. The Transcription Factor Encyclopedia. Genome Biology 2012 13(3):R24, 2012. (PMCID: PMC3439975)

86. Breuer, S, Chang, M.W., Yuan, J., and Torbett, B.E. Identification of HIV-1 Inhibitors Targeting the Nucleocapsid Protein. J. Med. Chem. 55(11):4968-4977, 2012. (PMCID: PMC3499629)

85. Federzoni, E.A., Valk, J.M.P., Torbett, B.E. Haferlach, T., Lowenberg, B., Fey, M.F., and Tschan, M.P. PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.Blood, 119(21):4963-4970, 2012. (PMCID: PMC3367898)

84. Yuan, J., Wang, J., Crain, K.C., Fearns, C., Kim, K.A., Hua, K.L., Gregory, P.D., Holmems, M.C., and Torbett, B.E. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T Cell resistance and enrichment. Mol. Ther. 20(4):849-859, 2012 (PMCID: PMC3321595)


83. Batliner, J., Buehrer, E., Federzoni, E.A., Jenal, M., Tobler, A., Torbett, B.E., Fey, M.F., and Tschan, M.P. Transcriptional regulation of miR-29b by PU.1 and c-Myc during neutrophil differentiation of APL cells. Brit. J. Hemat. Dec. 7, 2011. (PMID: 22145969)

82. Lugari, A., Breuer, S., Coursindel, T., Opi, S., Restouin, A., Shi, X., Nazabal, A., Torbett, B.E., Martinez, J., Collette, Y., Parrot, I., Arold, S.T., and Morelli, X. A specific protein disorder catalyzer of HIV-1 Nef. Bioorg. Med. Chem. 19(24):7401-7406, 2011. (PMID: 22061824)

81. Chun, H.B., Scott, T.M., Niessen, S., Hoover, H.S., Yates III, J.R., Torbett, B.E., and Eliceiri, B. The proteome of mouse brain microvessel membranes and basal lamina. J. Cerebral Blood Flow & Metabolism, July 27, 2011. (PMCID: PMC3323187)

80. Lin, Y.C., Perryman, A.L., Olson, A.J., Torbett, B.E., Elder, J.H. and Stout, C.D. Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease. Acta Crystallogaphica 67(pt6):540-548, 2011. (PMCID: PMC3107052)

79. Chang, M.W. and Torbett, B.E. Accessory mutations maintain stability in drug resistant HIV-1 protease. J. Mol. Biol. 410(4):756-760, 2011. (PMCID: PMC3139113)

78. Breuer, S., Sepulveda, H., Chen, Y., Trotter, J., and Torbett, B.E. A cleavage enzyme – cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease. Biochem.50(20):4371-4381, 2011. (PMCID: PMC319576)

77. Batliner, J., Mancarelli, M.M., Jenal, M., Reddy, V.A., Fey, M.F., Torbett, B.E. and Tschan, M.P. CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation. Mol. Immunol.48:714-719, 2011. (PMCID: PMC3026634)


76. Chang, M.W., Ayeni, C., Breuer, S., and Torbett, B.E. Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina. PLoS One, Aug 4;5(8). pii: e11955, 2010. (PMCID: PMC2915912)

75. Chang, M.W., Giffin, M.J., Muller, R., Savage, J., Lin, Y.C., Hong, S., Jin, W., Whitby, L.R., Elder, J.H., Boger, D.L., and Torbett, B.E. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem. J. 429:527-532, 2010. (PMCID: PMC3084599)

74. Lin, Y.C., Torbett, B.E., and Elder, J.H. Generation of infectious Feline Immunodeficiency Virus encoding FIV/human immunodeficiency virus chimeric protease. J. Virol.84:6799-6809, 2010. (PMCID: PMC2903298)

73. Jenal, M., Batliner, J., Reddy, V.A., Haferlach, T., Toblelr, A., Fey, M.F., Torbett, B.E., and Tschan, M.P. The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1. Leukemia 24:1073-1076, 2010.


72. Grant, C.K. Fink, E.A., Sundstrom, M., Torbett, B.E., and. Elder, J.H. Long-term survival and improved health status of FIV infected cats is associated with presence of neutralizing autoantibodies to the primary receptor, CD134. Proc. Natl. Acad. Sci. 106:19980-19985, 2009. (PMCID: PMC2775039)

71. Luxen, S., Noack, D., Frausto, M., Torbett, B.E. and Knaus, U.G.  Heterodimers formation and distinct localization of ROS-generating Duox/DuoxA enzymes in long epithelial cells.  J. Cell Sci.122:1238-47, 2009. (PMCID: PMC2714442)

70. Thrash, J.C., Torbett, B.E., Carson, M.J. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: Implications for Nasu-Hakola Disease. Neurochem Res. 34(1):38-45, 2009. (PMCID: PMC2655126)

2005 – 2008

69. Miller, R., Cirulli, V., Diaferia, G.R., Ninniri, S., Hardiman, G., Torbett, B.E., Benezra, R., and Crisa, L. Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes 57:2402, 2008. (PMCID: 2518491)

68. Giffin, MJ., Heaslet, H., Cauvi, G., Brik, A., Lin, Y-C., Stout, C.D., Wong, C-H., Elder, J.H., and Torbett, B.E. AB2, an azide-alkyne click compound, is a potent inhibitor of a multidrug-resistant mutant protease arising from protease inhibitor selection. J. Med. Chem. 51:6263, 2008. (PMCID: 2744648)

67. Fang, J., Menon, M., Zhang, D., Torbett, B., Oxburgh, L., Tschan, M., Houde, E., and Wojchowski, D.M. Attenuation of EPO-dependent erythroblast formation by death associated protein kinase 2. Blood 112:886, 2008.

66. Britschgi, C., Jenal, M., Arvidsson, G., Rizzi, M., Torbett, B.E., Mueller, B.U., Andres, A.-C., Tobler, A., Fey, M.F., Tschan, M.P. HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation. Brit. J. of Haem. 141: 179, 2008.

65. Blancafort, P., Tschan, M.P., Bergquist, S., Guthy, D., Brachat, A., Sheeter, D.A., Torbett, B.E., Edrman, D., Barbas, C.F. III. Modulation of drug resistance by artificial transcription factors. Mol. Cancer Ther. 7:688, 2008.

64. Tschan, M.P., Reddy, V.A., Torbett, B.E. PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity. Oncogene 27:3489, 2008.

63. Tschan, M.P., Gullberg, U., Shan, D., Torbett, B.E., Fey, M.F., Tobler, A. The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Leukemia 22: 1087, 2007.

62. Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B.E., Tenen, D.G., Friedman, A.D. C/EBPa binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood 110:3136, 2007.

61. Heaslet, H., Rosenfeld, R., Giffin, M., Lin, Y.C., Tam, K., Torbett, B.E., Elder, J.H., McRee, D.E., Stout, C.D. Conformation flexibility in the flap domains of ligand-free HIV protease. Acta. Crystallogr. D. Biol. Crystallogr. 63:866, 2007.

60. Rizzi, M., Tschan, M.P., Britschgi, C., Britschgi, A., Grob, T.J., Hugli, B., Leupin, N., Torbett, B.E., Ziemiecki, A., Fey, M.F., and Tobler, A. The death-associated protein kinase 2 (DAPK2) is upregulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. J. Leukocyte Biol. 81:1599, 2007.

59. Heaslet, H., Lin, Y.-C., Tam, K., Torbett, B.E., Elder, J.H., and Stout, C.D. Crystal structure of an FIV/HIV chimeric protease complexled with the broad-based inhibitor, TL-3. Retrovirology 4:1, 2007.

58. Manuel, E.R., Charini, W.A., Sen, P., Peyerl, F.W., Kuroda, M.J., Schmitz, J.E., Autissier, P., Sheeter, D.A., Torbett, B.E., Letvin, N.L. Contribution of TCR Repertoire Breadth to the Dominance of Epitopoe-Specific CD8+ T Lymphocyte Responses. J. Virol. 80:12032, 2006.; PMID: 17035327; PMCID: PMC1676269

57. Lin, Y-C., Brik, A., Parseval, A., Tam, K., Torbett, B.E., Wong, C.H., and Elder, J.H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. J. Virol. 80:7832, 2006.

56. Cirulli, V., Zalatan, J., McMaster, M., Prinsen, R., Salomon, D.R., Ricordi, C., Meda, P., Torbett, B.E. and Crisa, L. The class I HLA repertoire of pancreatic islets comprises the non-classical class 1b antigen HLA-G. Diabetes 55: 1214-22, 2006.

55. Swan, C.H., Buhler, B., Tschan, M.P., Barbas, C.F. III, and Torbett, B.E. T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery. Gene Therapy, 13: 1480, 2006.

54. Swan, C.H. and Torbett, B.E. Can gene delivery close the door to HIV-1 entry after escape? J. Med. Primatology 35:236, 2006.

53. Heaslet, H., Kutilek, V.D., Morris, G., Elder, J.H., Lin, Y-C., Torbett, B.E., and Stout, D.C. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3. J. Mol. Biol., 356:967, 2006.

52. Britschgi, C., Rizzi, M., Grob, T.J., Tschan, M.P., Hugli, B., Reddy, V.A., Andres, A-C., Torbett, B.E., Tobler, A., and Fey, M.F. Identification of the p53 family-responsive element in the promoter region of the tumor osuppressor gene hypermethylataed in cancer 1. Oncogene 25: 2030, 2006.

2000 – 2004

51. de Rozieres, S., Swan, C. H., Sheeter, D.A., Clingerman, K.J., Lin-Y.-C., Huitron-Resendiz, S., Henriksen, S., Torbett, B.E. and Elder, J.H. Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3. Retrovirology 1:38, 2004.

50. Hildbrand, P., Cirulli, V., Prinsen, R. C., Smith, K. A., Torbett, B. E., Salomon, D. R., Crisa, L. The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors. Blood, 104:2010, 2004.

49. Segal, D.J., Gonclaves, J., Eberhardy, S., Swan, C.H., Torbett, B.E., Barbas, C.F. 3rd. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J. Biol. Chem., 279:14509, 2004.

48. Huitron-Resendiz, S., de Rozieres, S., Sanchez-Alavez, M., Bühler, B., Lin, Y-C., Lerner, D.A., Henriksen, N.W., Burudi, M., H.S., Torbett, B.E., Henriksen, S. Elder, J.H. Resolution and prevention of FIV-induced neurological deficits by treatment with the protease inhibitor, TL-3. J. Virol., 78:4525, 2004.

47. Criscuoli, M., Reddy, V., Torbett, B.E., and Eliceiri, B.P. Src kinase requirement for Erk1/2 activation in blood vessels during stroke. Endothelium, 10:341, 2003.

46. Kutilek, V.D., Sheeter, D.A., Elder, J.H. and Torbett, B.E. Is Resistance Futile? Current Drug Targets-Infectious Disorders, 3:295, 2003.

45. Tschan, M.P., Fischer, K.M., Fung, V.S, Pirnia, F., Borner, M.M., Fey, M. F. Tobler, A. and Torbett, B.E. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. J. Biol. Chem., 278:42750, 2003.

44. Gombat, A.F., Kwok, S.H., Anderson, K.L., Yamaguchi, Y., Torbett, B.E. and Koeffler, H.P. Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP and PU.1. Blood, 101:3265, 2003.

43. Beutler, E., West, C., Torbett, B.E. and Deguchi, H.A. Chimeric mouse model of Gaucher disease. Mol. Med., 8:247, 2002.

42. Torbett, B.E. Reporter Genes: Too much of a good thing? J. Gene Med. 4:478, 2002.

41. Manchester, M., Smith, K.A., Eto, D.S., Perkin, H. and Torbett, B.E. Targeting and hematopoietic suppression of human CD34+ cells by measles virus. J. Virol. 76:6636, 2002.

40. Bühler, B., Lin, Y-C., Morris, G., Olson, A., Wong, C.-H., Richman, D.D., Elder, J.H. and Torbett, B.E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3. J. Virol., 75:9502, 2001.

39. Anderson, K.L., Nelson, S., Perkin, H., Smith, K.A., Klemsz, M.J. and Torbett, B.E. PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45. J. Biol. Chem., 276:7637, 2001.

38. Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K.A., Mueller, B., Narravula, S., Torbett, B.E., Orkin, S.H. and Tenen, D.G. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood, 96:2682, 2000.

37. van der Laan, J.W., Lockey, C., Griffeth, B.C., Frasier, F.S., Wilson, C.A., Onions, D.E., Hering, B.J., Long, Z., Otto, E., Torbett, B.E. and Salomon, D.R. Infection by porcine endogenous retrovirus after islet xenotransplantation. Nature, 407:90, 2000.

36. Pelletier, A.J., van der Laan, L., Siani, M.A., Thompson, D.A., Torbett, B.E. and Salomon, D.R. Presentation of Chemokine SDF-1a by fibronectin mediates directed migration of T cells. Blood, 96;2683, 2000.

35. Mayrand, S.M., Healy, P.A., Torbett, B.E. and Green, W.R. Genetic resistance to the MAIDS virus, LP-BM5, maps to H-2d. Virology, 272:438, 2000.

34. Steinberger, P., Widhopf-Andris, J., Bühler, B., Torbett, B.E. and Barbas, III, C.F. Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion. P.N.A.S., 97:805, 2000.

33. Anderson, K.L., Perkin, H., Smith, K.A., Surh, C.D., Venturini, S., Maki, R.A. and Torbett, B.E. PU.1 regulates development of thymic and hematopoietic progenitor derived (myeloid) dendritic cell populations. J. Immunol., 164:1855, 2000.


32. Crisa, L.C., Cirulli, V., Smith, K.A., Ellisman, M., Torbett, B.E. and Salomon, D.R. Human cord blood progenitors sustain thymic T-cell development and a novel form of angiogenesis. Blood, 943:298, 1999.

31. Kim, Y.-M., Kang, H.-S., Paik, S.-Gi., Pyun, K.-H., Anderson, K.L., Torbett, B.E. and Choi, I. Roles of ICSBP and PU.1 in regulating IL-18 gene expression. J. Immunol., 163:200, 1999.

30. Anderson, K.L., Smith, K.A., Perkin, H., Anderson, C.-G., Hermanson, G., Jolly, D.J., Maki, R.A. and Torbett, B.E. PU.1 and the M-CSF and G-CSF receptors play distinct roles in late-stage myeloid differentiation. Blood, 94: 1999.

29. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M. and Torbett, B.E. HIV vectors efficiently transduce human CD34+ cells that mediate long-term engraftment of NOD/SCID mice. Science, 283:682, 1999.

28. Pedroza-Martins, L., Gurney, K., Torbett, B.E. and Uittenbogaart, C.H. Differential tropism and replication kinetics of HIV-1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the post-entry level. J. Virol. 12:9441, 1998.

27. Anderson, K.L, Smith, K. A., Pio, F., Torbett, B.E. and Maki, R.A. PU.1 null neutrophils are functionally deficient and fail to terminally differentiate. Blood, 92:1576, 1998.

26. Lee, T., Laco, G.S., Torbett, B.E., Fox, H.S., Lerner, D.L., Elder, J.H. and Wong, C-H. Analysis of the S3 and S3’ subsite Specificities of the FIV Protease; Development of a broad-0-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo. P.N.A.S. 95:939, 1998.

25. McKercher, S., Torbett, B.E., Anderson, K.L., Henkel, G., Vestal, D.J., Klemsz, M., Feeney, A.J., Wu, G.E., Paige, C.J. and Maki, R.A. Targeted disruption of the PU.1 gene results in hematopoietic abnormalities. EMBO. J., 15:5647, 1996.

24. Anderson, K.L., Smith, K.A., Conners, K., McKercher, S., Maki, R.A. and Torbett, B.E. Myeloid development is selectively disrupted in PU.1 null mice. Blood, 91:3702, 1998.

1990 – 1994

23. Torbett, B.E. and Mosier, D.E. Does preferential Th subset activation contribute to the murine acquired immunodeficiency disease MAIDS? Forum Immunol., 145:696, 1994.

22. Ucker, D.S., Hebshi, L.D., Blomquist, J.F. and Torbett, B.E. Physiological T cell death: Susceptibility is modulated by activation, aging, and transformation, but the mechanism is constant. Immunol. Rev. 142:273, 1994.21. Van Kyuk, R., Torbett, B.E., Gulizia, R.J., Leath, S., Mosier, D.E. and Koenig, S. Cloned human CD8+ cytotoxic T lymphocytes protect human-PBL-SCID mice against HIV-1 infection by an HLA-unrestricted mechanism. J. Immunol. 153:4826, 1994.

20. Reinhardt, B., Torbett, B.E., Gulizia, R.J, Reinhardt, P.P., Spector, S.A. and Mosier, D.E. Human immunodeficiency virus type 1 infection of neonatal severe combined immunodeficient mice xenografted with human cord blood cells. AIDS Res and Human Retrovirus 10:131, 1994.

19. Hobbs, M.V., Weigle, W.O., Noonan, D.J., Torbett, B.E., McEvilly, R.J., Koch, R.J., Cardenas, G.J. and Ernst, D.N. Cytokine gene expression by CD4 T cells from young and old mice. J. Immunol. 150:3602, 1993.

18. Mosier, D.E., Gulizia, R.J., MacIsaac, P.D., Torbett, B.E. and Levy, J.A. HIV-1 rapid CD4 T cell depletion in human-PBL-SCID mice by non-cytopathic macrophage-tropic isolates of HIV. Science 260:689, 1993.

17. Mosier, D.E., Gulizia, R.J., MacIsaac, P.D. and Torbett, B.E. HIV-1 strain-dependent CD4 T cell depletion in hu-PBL-SCID mice. Prog. in Immunol. 725, 1993.

16. Gahring, L.C., Ernst, D.N., Romball, C.G., Hobbs, M., Torbett, B.E. and Wiegle,W.O. The expression of CD45RB on CD4 lymphocytes: Mouse strain polymorphism and different responses to distinct antigens. Cell. Immunol. 148:269, 1993.

15. Mosier, D.E., Stell, K.L., Gulizia, R.J., Torbett, B.E. and Gilmore, G. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J. Exp. Med. 177:191, 1993.

14. Mosier, D.E., Picchio, G., Kirven, M.B., Garnier, J.L., Torbett, B.E., Baird, S.M. Kobayashi, R. and Kipps, T.J. EBV-induced human B cell lymphomas in hu-PBL-SCID mice. AIDS Res. and Human Retrovirus 8:735, 1992.

13. Wineman, J.P., Gilmore, G. Gritzmacher, C., Torbett, B.E. and Muller-Siegberg, C.E. CD4 is expressed on murine pluripotent stem cells. Blood 80:1717, 1992.

12. Torbett, B.E., Picchio, G. and Mosier, D.E. hu-PBL-SCID mice: A model for human immune function, AIDS and lymphomagenesis. Immunol. Rev. Vol. 124:139, 1992.

11. Mosier, D.E., Gulizia, R.J., Torbett, B.E., Baird, S.M. and Wilson, D. Break For SCIDs. Nature. 353:509, 1991.

10. Hobbs, M.V., Ernst, D.N., Torbett, B.E., Glasebrook, A.L., Rehse, M.A., McQuitty, D.M., Thoman, M.A., Bottomly, K., Rothermel, A.L., Noonan, D. and Weigle, W.O. Cell proliferation and cytokine production by CD4 cells from old mice. J. Cell. Biochem. 46:312, 1991.

9. Ernst, D.N., Hobbs, M.V., Torbett, B.E., Glasebrook, A.L., Rehse, M.A., Bottomly, K., Hayakawa, K., Hardy, R.R. and Weigle, W.O. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4 T cells from young and aged mice. J. Immunol. 145:295, 1990.

8. Torbett, B.E. and Glasebrook, A.L. Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 populations. Immunol. Letters 23:227, 1990.

1985 – 1989

7. Firestein, G.S., Roeder, W.D., Laxer, J.A., Townsend, K.S., Weaver, C.T., Horn, J.T. Linton, H.J., Torbett, B.E. and Glasebrook, A.L. A new murine CD4 T cell subset with an unrestricted cytokine profile. J. Immunol. 143:518, 1989.

6. Saxton, R.E., Burke, M.W., Torbett, B.E., Fairhurst, M., Morton, D.L. and Cochran, A.J. Detection of malignant melanoma with monoclonal antibodies. Disease Markers. 6:97, 1988.

5. Gorman, K.C., Blakely, A., Liu, C.-C., Young, J.D., Torbett, B.E. and Clark, W.R. Cloned cytotoxic T lymphocytes as target cells. Polarity of lysis revisited. J. Immunol. 141:2211, 1988.

4. Clark, W.R., Ostergaard, H., Gorman, K.C. and Torbett, B.E. Molecular mechanisms of CTL-mediated lysis: A cellular perspective. Immunol. Rev. 103:37, 1988.

3. Torbett, B.E. and Clark, W.R. The role of accessory molecules in T-helper activation induced by antigen, lectin, or CD3 antibodies. Cell. Immunol. 115:352, 1988.

2. Torbett, B.E., Skidmore, B. and Clark, W.R. Multiple pathways for antigen-independent activation of a T-helper hybridoma. Eur. J. Immunol. 16:933, 1986.

1980 – 1984

1. Torbett, B.E., Carey, A.B. and Marquardt, W.C. A new species of Eimeria from the Golden-Mantled ground squirrel, Spermophilus lateralis, in Northern Colorado. J. Proto. Zool. 29:157, 1982.